36 for the most common version, by using a GoodRx coupon. Ophthalmic atropine, homatropine, and scopolamine are used to dilate (enlarge) the pupil of the eye. Classification. The information below refers to products available in the United States that contain scopolamine. Devil's Breath is derived from the flower of the “borrachero” shrub, common in the South American country of Colombia. When deciding to use medications remember to weigh risks versus benefits 4. Scopolamine can cause drowsiness, disorientation, and confusion. Scopolamine has been used to establish amnesia models, the dosage of scopolamine ranging from 0. Recommended Adult Dosage. Comment: The patch should be kept in place for 24 hours following surgery. scopolamine [sko-pol´ah-mēn] an anticholinergic and antimuscarinic alkaloid derived from various plants, having a depressant effect on the central nervous system. Check with your doctor immediately if any of the following side effects occur while taking scopolamine: More common. Hyoscine terdiri dari dua jenis, yaitu hyoscine butylbromide dan hyoscine hydrobromide. In its peripheral actions, scopolamine differs from atropine in that it is a stronger blocking agent for the iris, ciliary body and salivary, bronchial and sweat glands but is weaker in its action on the heart (in. It works on the central nervous system (CNS) to create a calming effect. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects) benztropine and scopolamine both decrease cholinergic effects/transmission. Mariani EP, Southard BJ, Woolever JT, et al. scopolamine hydrochloride scopolamine HCl An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Medically reviewed by Drugs. Maximum serum concentrations of scopolamine occurred 10 to 30 minutes after drug administration. What is belladonna alkaloids and phenobarbital? belladonna alkaloids and phenobarbital is made up of belladonna alkaloids (atropine, hyoscyamine, scopolamine) and phenobarbital. There were no missing. difficulty urinating. The scopolamine transdermal system is a circular, 1. If you or someone you know has overdosed on Scopolamine, it’s important to seek medical help immediately. 3. Pharmacologic: anticholinergics + + + Indications + + Transdermal: Prevention of motion sickness. itching and swelling at the application site. See what others have said about Scopolamine Transdermal (Transderm-Scop), including the effectiveness, ease of use. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. 6% of nonmetabolized L-(-)-scopolamine is excreted in urine, a first-pass metabolism is suggested to occur after oral administration of scopolamine. 5-mg patches applied topically and changed every 72 hours) May also help to decrease oral secretions: Benzodiazepines: Lorazepam (Ativan; 0. If the patient does not have IV access, what other pharmacologic option do you have? Atropine 1% ophthalmic solution 1-2 gtts SL q 1-2 hours. It is used to prevent nausea and. The patch is placed on the skin, behind the ear, and left on the body for a certain amount of time. Generic name: Scopolamine Transdermal Patch [ skoe-POL-a-meen ] Brand name: Transderm Scop. o) of synthesized compounds, respectively. Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine. scopolamine (skoe-pol-a-meen) Isopto Hyoscine, Transderm-Scop, Transderm-V. Scopolamine transdermal system is designed for continuous release of scopolamine following application to an area of intact skin on the head, behind the ear. Each patch contains 1. 8 published the first confirmed case of CS by scopolamine in our country. Of the total drug interactions, 8 are major, 316 are moderate, and 17 are minor. Scopolamine, also known as burundanga, is a tropical alkaloid produced by species of plants such as Hyoscyamus albus and Datura stramonium. 0 2,4]nonan-7-yl) 3-hydroxy-2 phenylpropanoate. SCOPOLAMINE Scopolamine is naturally plant obtained alkaloid drug, obtained from family of Solanaceae, such as nightshade, jimsonweed and henbane. drowsiness. To examine whether 5-HT3 receptors are affected by scopolamine we examined. Drooling is common in children with neurological disorders, but its management is very challenging, Scopolamine transdermal patch (STP) appears to be useful in controlling drooling, although it is not approved for this indication and there are limited clinical studies about its effectiveness. The further back in time we go, the more murky and oftentimes grisly the stories become. But there are a number of urban myths circulating about Scopolamine For example, according to figures reported by t he Valle de Aburrá Metropolitan Police, by May 2023, there are 373 cases of theft with scopolamine have been reported in the city. Consider more frequent monitoring during treatment with Transderm Scōp in patients suspected of having intestinal obstruction, patients with pyloric obstruction or urinary bladder neck obstruction and. Apply the patch to a clean, dry, and intact skin area behind your ear. 36 for the most common version, by using a GoodRx coupon. Atropine is also given by injection to help relax the stomach and intestines for certain types of procedures. dilated pupils. , naloxone and midazolam) of 30 min or less. Other Drugs In Same Class. 5 mg scopolamine formulated to deliver in vivo approximately 1 mg over 3 days. It is also used to prevent nausea and vomiting caused by motion sickness. Merative, Micromedex. What in the world? I hadn’t even thought of that. Management of terminal secretion is primarily to decrease the distress of loved ones 3. 8 out of 10 from a total of 52 ratings on Drugs. [PubMed 256991] 636. Masuk dengan Email. 81. Scopolamine is also used to prevent nausea and vomiting after anesthesia and surgery. dizziness. -3 rating. Scopolamine is a widely used model to study dementing-related illnesses since it can induce memory and cognitive deficits. Scopolamine has an average rating of 5. . 5-HT3 receptor antagonists are used for the same purpose and are structurally related to scopolamine. Scopolamine, a centrally active muscarinic antagonist, has been used to model dementia and to demonstrate the pharmacological effects of cholinergic drugs, but for most effects the. anticholinergic effects (dry mouth, blurred vision, constipation, dizziness, difficulty urinating) withdrawal symptoms (dizziness, nausea, and vomiting) if used over 3 days. Learn about its uses, side effects, interactions and more from Cleveland Clinic. 5mg over a 3-day period. Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. 86 per 1, 4 Patch 72 Hour Patch 72 Hour, but you can pay just $14. Scopolamine, also known as Devil’s Breath, is a drug used in Colombia for the purpose of robbery. seizures. The antiemetic guidelines established at our hospital allow children between 8 and 15kg to receive a ½ patch every 3 days and children greater than 15 kg to. 0 mg q 72 h. 55-7. 43% of reviewers reported a positive experience, while 39% reported a. However, by acting as an M1-muscarinic antagonist, it is non-sedating and does not prolong the QTc. The following side effects may get better over time as your body gets used to the medication. During anesthesia and surgery, atropine, glycopyrrolate, hyoscyamine, and scopolamine are used to help keep the heartbeat normal. SCOPOLAMINE PATCH has a VA Formualry status of 'Formulary Item' and is within VA. Intranasal scopolamine (IN SCOP) is attractive because it can be fast acting and work when gastric motility is slowed. Scopolamine is in a class of medications called antimuscarinics. Drug Information: Scopolamine is an alkaloid that inhibits the muscarinic receptors for acetylcholine. In its most common form, it comes as a patch that a person with motion sickness wears behind the ear. DOPAMINE ANTAGONISTS. tunnel vision. It is also sometimes used before surgery to decrease. Scopolamine 8/9. The pharmaceutical version of the drug comes in a patch used to treat nausea and vomiting while at sea. , concentration of. 19568. It belongs to the group. 5. Scopolamine / pharmacology*. confusion. 2 mg SQ q 4-6 h (can be given by continuous infusion, 0. 5 out of 10 from a total of 204 ratings on Drugs. decreased flow of breast milk. Elderly and pediatric patients may be more sensitive to the neurological and psychiatric effects of scopolamine transdermal system. Scopolamine is (9-methyl-3-oxa-9-azatricyclo[3. 50 Hz) on qEEG compared with placebo. Overdose: Muscle weakness. However, it is commercially available as the hydrobromide, a tertiary structured. Scopolamine can cause drowsiness, disorientation, and confusion. 3 mg of scopolamine base. Mice received transdermal patches of scopolamine (0. 5 mg ® ® Each patch contains 1. It is commonly used in research and has some medical applications. Once you’ve applied a patch, it lasts for up to 3 days. Scopolamine is a generic medication, often referred to by its brand name, Transderm-Scop. Its many uses include an anesthetic premedication, the treatment of URINARY. ARTICLES & WRITINGS # A Curious Cure - Erowid Extracts, Nov 2008. g. It has a tertiary amine structure like atropine and, as such, is well absorbed when given by most routes. Scopolamine is made from the Borrachero tree, which is commonly found in Colombia. It has a tertiary amine structure like atropine and, as such, is well absorbed when given by most routes. Scopolamine is a medication used to manage and treat postoperative nausea and vomiting (PONV) and motion sickness. It competitively blocks 5-hydroxytryptamine (HT 3) receptors, with IC 50 2. Additional Info. For oral dosage form (tablets): To treat urinary problems or intestine problems or painful menstruation: Older adults, adults, and teenagers—10 to 20 milligrams (mg) three or four times a day. V. 2 mm thick and 2. ChEBI. Dry mouth, drowsiness, and blurry vision are common side effects. Scopolamine has an average rating of 5. Schmidt first isolated it from the Scopolia japonica, so named it as scopolamine. Scopolamine is an anticholinergic medication that is used to treat motion sickness an. Scopolamine may be administered transdermally using a special delivery system that gradually releases scopolamine onto the skin over a period of days. Call 717. It is in. The only other significant side-effect was dryness of mucous membranes. Pronunciation of scopolamine with 3 audio pronunciations. The scopolamine skin patch included a reservoir of the drug containing 1. Department of Otolaryngology, Hasharon Hospital, Golda Medical Center, Petah Tikvah, Israel. Scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. 5 mg/kg and 15 mg/kg (p. , 2019. rate; decr. In acute overdosage, the main clinical problem is central nervous system (CNS) depression. The scopolamine transdermal system is a circular, 1. 2 mg/day IV or SQ). 4,6 Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. Scopolamine hydrobromide differs in several significant ways from atropine. It antagonizes mismatch‐induced suppression of noradrenergic neural transmission 6. Scopolamine belongs to the group of medicines called anticholinergics. Our cruises have been cancelled the last two years and my (very expensive!) Scopolamine patches expired Sept 2021, according to the box. Its effect was maintained for 72 h. 35 and a pKa of 7. com. risk of profound CNS and resp. The accomplishment marks the first time SwRI has fully synthesized a drug compound that is naturally derived from plants. Drowsiness is a common side effect of motion sickness drugs. 2003). Scopolamine and pregnancy. Although not all of these side effects may occur, if they do occur they may need medical attention. headache. Doctors noted that women in. In Australia, tablets containing scopolamine. Driving, steering, or flying to your destination after taking a dose is definitely not advisable. 35 and a pKa of 7. Scopolamine is in a class of medications called antimuscarinics. When applying a scopalamine (Transderm Scop) patch, the nurse should ensure that the patient's skin is ______ and ______. Along with its needed effects, scopolamine may cause some unwanted effects. Use some other kind of birth control also like a condom when taking this. Each system contains 1. It is also used to prevent nausea and vomiting caused by motion sickness. Scopolamine is a nonselective reversible inhibitor of muscarinic receptors. Scopolamine Methyl Bromide. Atropine and scopolamine are muscarinic receptor antagonists with amnestic properties that have been used for decades in experimental animals to induce impairment in their performance of a variety of tasks requiring intact working and reference memory [1–3]. Well, sea sickness times 10. Hospice A accounted for 73% of the participants. Scopolamine, also known as “hyoscine”, is most commonly utilised for the management of post-operative nausea, motion sickness and hypersalivation secondary to psychotropic medications such as clozapine [14–16]. Scopolamine is an oral, intravenous, ophthalmic or topical drug with many uses including the prevention of motion sickness. Scopolamine, also known as hyoscine, is a tropane alkaloid drug with muscarinic antagonist effects. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)A Cochrane review of 14 RCTs with a total of 1,025 participants who had sea- or lab-induced motion sickness compared scopolamine with placebo and various other agents. Avoid use of TRANSDERM SCŌP in patients with severe preeclampsia. Call your doctor for medical advice about side effects. temporary changes in heart rate such as palpitations. Scopolamine (Transderm-Scop) is a medication prescribed for the prevention of nausea and vomiting after surgery and from motion sickness. Scopolamine has a molecular weight of 303. Scopolamine. This medicine is made up of belladonna alkaloids (atropine, hyoscyamine, scopolamine) and phenobarbital. clean & dry. procamine A, B, pamine, and protease-inhibitors), biogenic amines (histamine, dopamine, noradrenaline, norepinephrine, neurotransmitters) and other compounds such as amino acids (γ-aminobutyric acid, α-amino acids), carbohydrates (glucose, fructose), pheromones (Iso-pentyl acetate, n-buttyl acetate, iso-pentanol, n. loss of memory. Scopolamine plus d‐ amphetamine has been proven to be most effective against severe motion sickness 10. Sara Tullberg, in xPharm: The Comprehensive Pharmacology Reference, 2007. 1 mm thick, 2. America and Europe and is known for causing delirious states and poisonings. Scopolamine is an anticholinergic drug; it inhibits the action of acetylcholine, a ubiquitous neurotransmitter responsible for a wide variety of physiological responses: Scopolamine transdermal patch is used to prevent nausea and vomiting after anesthesia, narcotic pain medicines, and surgery. A multi-center randomized controlled trial was initiated to identify whether glycopyrronium or scopolamine was more effective in treating drooling in children with non-progressive neurodisability, and showed that scopolamine and glycopyrrolate were both clinically effective in treating drooling, but scopolamine produced more problematic side. “Truth serum” refers to various drugs that have been used in attempts to extract truthful statements from people. ), and corkwood (Duboisia species [2]). scopolamine + codeine avoid combo if antitussive use; otherwise monitor resp. The Negatives of Scopolamine. Scopolamine did not affect blood pressure variability. This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. The scopolamine transdermal system is a circular, 1. You could have more side effects. Scopolamine is a natural product and is familiar to many people as a motion sickness medicine. De naam van de vrucht is ‘cacao sabanero’. Donepezil treated were administered 2 mg/kg (p. -1 rating. Scopolamine Transdermal (Transderm-Scop) received an overall rating of 6 out of 10 stars from 4 reviews. 1. Scopolamine is a medication that helps prevent nausea and vomiting associated with motion sickness, irritable bowel syndrome, Parkinson's disease and other intestinal. The first uses of Scopolamine as medicine started in the 1900s as anesthesia. clodronate ; denosumab(120mg/1. Scopolamine (Transderm Scop) is an anticholinergic. Use Caution/Monitor. Reduction of salivary flow with transdermal scopolamine: a four-year experience. g. Scopolamine-induced memory disorders are associated with increased oxidative stress in the brain [34, 35] characterised by an increased MDA concentration which is a harmful effect of reactive oxygen species . 81. Scopolamine hydrobromide [Canadian product]: Injection: Adjunct to anesthesia to produce sedation and amnesia. g. Proper Use. The drug is called scopolamine, but more commonly referred to as Devil's Breath, is made from the seeds of the borrachero tree . Borrachero has been used for hundreds of years by native South Americans in spiritual rituals. It is used to treat GI (gastrointestinal) spasms. No information is available on the use of scopolamine during breastfeeding. The inactive components are light mineral oil, polyisobutylene, polypropylene and aluminized polyester film. scopolamine – oral, parenteral, patch; Bone metabolism regulators. Thus, scopolamine is a promising candidate for. These chemicals relax muscles lining the digestive and urinary. Scopolamine penetrates the blood-brain barrier, readily blocking cholinergic transmission in the CNS. スコポラミン（英: scopolamine ）は、トロパンアルカロイドでムスカリン受容体 拮抗薬の一種。ヒヨスチン (hyoscine)ともいう。アセチルコリンのムスカリン受容体への結合を競合的に阻害することによって抗コリン作用を有する。The commonest side effects reported for scopolamine therapy are sedation, dry mouth, blurry vision, central cholinergic syndrome, and confusion ( Apfel et al. The name of its fruit is “cacao sabanero” and each contains around 30 seeds. Isobolographic analyses indicated that 1. Each system contains 1. No information is available on the use of scopolamine during breastfeeding. Like atropine,scopolamine + codeine avoid combo if antitussive use; otherwise monitor resp. It has a tertiary amine structure like atropine and, as such, is well absorbed when given by most routes. Best to make an appointment and speak with your doctor. Wikimedia Commons Doctor Hawley Harvey Crippen, famously hanged for the murder of his wife, who he allegedly dispatched with devil’s breath. o) of donepezil. sore throat. The intraoperative course was unremarkable. C. Scopolamine is a nonselective reversible inhibitor of muscarinic receptors. Deductible. The medication is also available in an intravenous form. The most frequently reported side effects with transdermal scopolamine are visual disturbances and dry mouth. Ophthalmic atropine, homatropine, and scopolamine are used to dilate (enlarge) the pupil of the eye. 1. Scopolamine has a molecular weight of 303. The plaster contains a reservoir of 1. Transderm Scop is scopolamine administered topically (through the skin or transdermally) via a special delivery system that gradually releases scopolamine onto the skin over a period of three days. [6] [7] It is also used to improve excessive respiratory secretions at. blurred vision. It is in the anticholinergic class of drugs. Record the pronunciation of this word in your own voice and play it to listen to how you have pronounced it. It produces both peripheral anti-muscarinic properties and central sedative, antiemetic and amnestic effects. This draft guidance, when finalized, will represent the current thinking of the Food and Drug Administration (FDA, or the Agency) on this topic. 55-7. The scopolamine transdermal system is a circular, 0. Because of its short half. It is obtained from plants of the family Solanaceae (nightshades), such as henbane or jimson weed (Datura species). shaking. There have been multiple reports of poisonings, including accidental. Proceeding from the visible surface towards the surface attached to the skin, these layers are: (1) a backing layer composed of a tan colored, pigmented, flexible film. Brand names: Transderm-Scop. Because only 2. Proceeding from the visible surface towards the surface attached to the skin, these layers are: (1) a backing layer of tan-colored, aluminized, polyester film; (2) a drug. By blocking this. Scopolamine ophthalmic side effects. Scopolamine, also known as hyoscine is a tropane alkaloid found in plants belonging to the family of Solanaceae like Datura stramonium, Brugmensia, Atropa belladona (deadly nightshade) or Hyoscyamus niger (black henbane) []. Scopolamine has a molecular weight of 303. 75-12. , 2010 ). No significant side effects were. Proceeding from the visible surface towards the surface attached to the skin, these layers are: (1) a backing layer of peach-colored polyethylene/polyester film printed with brown ink; (2) a. , 1993). Scopolamine is a non-selective competitive inhibitor of muscarinic receptors for acetylcholine, and. Scopolamine is readily racemized in the presence of dilute alkali. Alzheimer's disease, a progressive neurodegenerative disease, affects learning and memory resulting from cholinergic dysfunction. Highest contamination levels detected in fennel, cloves and coriander. 4-1. At the same time, scopolamine. Avoid use of scopolamine transdermal system in patients with severe preeclampsia. doi: 10. 75-12. Discontinue TRANSDERM SCŌP if signs or symptoms of cognitive impairment develop. Each system contains 1. It is mainly produced in Colombia, where it is used to make victims. Introduction. com. It is also sometimes used before surgery to decrease saliva. However, there may be risks from using scopolamine if you have preeclampsia during pregnancy. Following IV administration of a 0. Glycopyrrolate has been widely used as a preoperative medication to inhibit salivary gland and respiratory secretions. Meclizine has an average rating of 7. Information last revised July 2023. $4 – $21. American living in Colombia, in 2009 my drink was spiked with Scopolamine which completely altered my state of mind but not to the point of losing consciousness. 東莨菪鹼通過在毒蕈鹼乙酰膽鹼受體，充當競爭性拮抗劑發揮其效用；因而它被分類為 抗膽. In unstable bradycardic patients, paramedics will often. A priming. Scopolamine can cause atrophy and degeneration of brain neurons in mice [37,40]. FDA Labeled Indications [1] [2] There are two FDA approved indications for the use of scopolamine: How Scopolamine (Transderm Scop) works. 4 Gastrointestinal and Urinary Disorders Scopolamine, due to its anticholinergic properties, can decrease gastrointestinal motility and cause urinary retention. Scopolamine has a molecular weight of 303. 2 mm thick and 2. 5,6 Although scopolamine is available in. Scopolamine has marked amnesic effects, and is used in Alzheimer’s research. scopolamine patch to use for the trip. Scopolamine, also known as burundanga, is a chemical substance made from the scopolia plant. Detailed Atropine / Hyoscyamine / Phenobarbital / Scopolamine dosage information for adults and children. Scopolamine transdermal system is designed for continuous release of scopolamine following application to an area of intact skin on the head, behind the ear. Limited dispense for PONV only upto 4 patches with no refills. They are used before eye examinations, before and after eye surgery, and to treat certain eye conditions, such as uveitis or posterior synechiae. Scopolamine is also used to prevent nausea and vomiting after anesthesia and surgery. How Scopolamine (Transderm Scop) works. You can not determine if the drug has lost its. It works on the central nervous system (CNS. nausea or vomiting. Scopolamine (Transdermal Route) Description and Brand Names Before Using Proper Use Precautions Side Effects Products and services Proper Use Drug. Drooling. The patch should be applied 24 hours prior to surgery and removed 24 hours after surgery. Scopolamine subjects experienced less nausea compared with subjects given meclizine or placebo. Recent studies have reported that Scopolamine increases the accumulation of reactive oxygen species that induces oxidative stress leading to memory impairment . However, it is commercially available as the hydrobromide, a tertiary structured. , and other Solanaceae plants. Scopolamine became the first drug commercially available as a transdermal therapeutic system used for extended continuous drug delivery during 72 hours. It is also used to prevent nausea and vomiting caused by motion sickness. Scopolamine transdermal patch is a medicine that prevents nausea and vomiting after anesthesia, narcotic pain medicines, and surgery. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Scopolamine is a non-competitive antagonist at muscarinic acetylcholine receptors, which was used many years. Scopolamine (Transderm Scop) is an anticholinergic. 1 Uses of these plants around the world range from food to ornaments to medicinal preparations that take advantage of their strong anticholinergic, antiemetic, and hallucinogenic properties. Ask your doctor or pharmacist for more information. . In the clinic, the routes of administration of. Answer: Scopolamine is a very long-acting dilating drug when used in the eye. , off-label uses, dosing, pharmacodynamics, pharmacokinetics. Hyoscyamine (Scopolamine®) 0. Maximum serum concentrations of scopolamine occurred 10 to 30 minutes after drug administration. 43% of reviewers reported a positive effect, while 39% reported a negative effect. g. We're set to finally cruise again on March 25, 2022. 5% scopolamine was reached 20 to 30. Last updated on Jul 27, 2023. Get scopolamine for as low as $27. Therapeutic: antiemetics. Brugmansia spec. Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual. How to Use the Scopolamine Patch Scopolamine comes as a round patch with 1 sticky side. Scopolamine is a nonselective reversible inhibitor of muscarinic receptors. Scopolamine transdermal system is designed for continuous release of scopolamine following application to an area of intact skin on the head, behind the ear. How to use scopolamine transdermal system: Inside the scopolamine transdermal system package, you will find one scopolamine transdermal system. The aim of this study was to explore the effect of. In 1910, Dr. com. dizziness. Post-Deductible. 81. Find information on Scopolamine (Transderm-Scop) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. g. 7 and 3. Scopolamine - Last updated on December 12, 2022 All rights owned and reserved by Memorial Sloan Kettering Cancer Center. Scopolamine makes the nerves that cause the vomiting reflex less active. Persons who are hypersensitive to scopolamine or to other belladonna . Excessive drooling, called sialorrhea, is a common symptom of Parkinson’s disease (PD) and can cause awkwardness in social situations. Scopolamine patches are the way to go. Of the total drug interactions, 8 are major, 316 are moderate, and 17 are minor. There are two FDA approved indications for the use of scopolamine: Postoperative nausea and vomiting (PONV) associated with recovery from anesthesia, opiate analgesia, and.